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Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment

Department of Psychiatry, LWL-University Hospital Bochum, Bochum, Germany, ida.haussleiter@ wkp-lwl.org

Martin Brüne

Department of Psychiatry, LWL-University Hospital Bochum, Bochum, Germany

Georg Juckel

Department of Psychiatry, LWL-University Hospital Bochum, Bochum, Germany

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Demyelinization of nerve fibres not only affects the motor and sensory systems functionally, but may also cause psychopathological signs and symptoms. In addition to the psychiatric manifestations of MS, many patients have reactive psychological problems that are often hard to distinguish from the `organic' causation of psychopathology. In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability.

Key Words: multiple sclerosis • psychiatric comorbidity • coping • outcome

Therapeutic Advances in Neurological Disorders, Vol. 2, No. 1, 13-29 (2009)
DOI: 10.1177/1756285608100325


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