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Review: Pathophysiology and treatment of bacterial meningitis

Department of Cell Biology and Neurobiology, Charité - Universitaetsmedizin Berlin, Berlin, Germany, Department of Neurology, LKH Klagenfurt, Klagenfurt, Austria joerg.weber{at}charite.de

Joerg R. Weber

Department of Neurology, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Bacterial meningitis is a medical emergency requiring immediate diagnosis and immediate treatment. Streptococcus pneumoniae and Neisseria meningitidis are the most common and most aggressive pathogens of meningitis. Emerging antibiotic resistance is an upcoming challenge. Clinical and experimental studies have established a more detailed understanding of the mechanisms resulting in brain damage, sequelae and neuropsychological deficits. We summarize the current pathophysiological concept of acute bacterial meningitis and present current treatment strategies.

Key Words: bacterial meningitis • meningoencephalitis • pneumococci • meningococci • dexamethasone

This version was published on November 1, 2009

Therapeutic Advances in Neurological Disorders, Vol. 2, No. 6, 401-412 (2009)
DOI: 10.1177/1756285609337975


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